So for the A380 I should eliminate the 4 engines and leave it with two?
That's certainly an interesting idea, but it would only be a thought experiment as there are no engines powerful enough to do that. Depends on how 'real world' you want your project to be.
I was also thinking of doing research on what different designs airbus uses to make their aircraft more effenct.
That sounds like an interesting line to follow, but if it's for a math project it might either be a bit vague or very complicated, depending on what information you could find. I imagine Airbus keep a lot of this stuff private (from Boeing for example).
I was also thinking of applying the airfoil
You've mentioned this a few times but I don't know what you actually mean. I thought it was perhaps something lost in translation as I guess you are from Argentina, so English is not your first language (though you seem fluent).
Aerofoils can be thicker or thinner depending on what is needed in terms of speed and lift, so you can't easily take the design from one aircraft and apply it to one that is substantially different in size, etc.
Talking of reality Scott Manley just today released a video that touches on some of this stuff, like the fact that wings have to have the required strength and the fuel needs to go somewhere:
(About 14 mins)